Common Side Effects

8.4

2025•23m

Sci-Fi & Fantasy

Former high school lab partners Marshall and Frances begin to unravel a conspiracy involving big pharma and the federal government to suppress knowledge of a rare mushroom that may hold the key to curing all the world’s diseases.

Production

Production

Available For Free On

Trailers & Videos

Thumbnail for video: Official Trailer [Adult Swim Europe]

Official Trailer [Adult Swim Europe]

Thumbnail for video: Official Trailer #3

Official Trailer #3

Thumbnail for video: Official Trailer #2

Official Trailer #2

Thumbnail for video: Official Trailer

Official Trailer

Thumbnail for video: Promo #5

Promo #5

Thumbnail for video: Early Preview: Marshall's Bounty Hunter

Early Preview: Marshall's Bounty Hunter

Thumbnail for video: Promo #4

Promo #4

Thumbnail for video: Sneak Peek: Rick & Frances

Sneak Peek: Rick & Frances

Thumbnail for video: Early Preview: Rick and Frances

Early Preview: Rick and Frances

Thumbnail for video: Sneak Peek: Copano & Harrington

Sneak Peek: Copano & Harrington

Seasons

10 Episodes • Premiered 2025

Still image for Common Side Effects season 1 episode 1: Pilot

1. Pilot

6.3

Marshall meets his old high school classmate Frances and lets her in on a world-changing secret.

Still image for Common Side Effects season 1 episode 2: Lakeshore Limited

2. Lakeshore Limited

6.5

Marshall's forced on the run as the DEA pursues him.

Still image for Common Side Effects season 1 episode 3: Hildy

3. Hildy

6.5

Marshall visits an old mentor as new pressures mount.

Still image for Common Side Effects season 1 episode 4: Dumpsite

4. Dumpsite

6.7

Frances tracks down Marshall in an unlikely location.

Still image for Common Side Effects season 1 episode 5: Star-Tel-Lite

5. Star-Tel-Lite

6.8

Marshall, Frances, and their crazy neighbors deal with the aftermath of a dangerous incident.

Still image for Common Side Effects season 1 episode 6: In the System

6. In the System

7.0

Stuck in jail, Marshall faces new threats.

Still image for Common Side Effects season 1 episode 7: Blowfish

7. Blowfish

6.8

A chance encounter offers a risky opportunity for escape.

Still image for Common Side Effects season 1 episode 8: Amelia & Wyatt

8. Amelia & Wyatt

7.0

Marshall and his new ally make a bold move.

Still image for Common Side Effects season 1 episode 9: Cliff's Edge

9. Cliff's Edge

7.3

Marshall's mushroom project grows out of hand.

Still image for Common Side Effects season 1 episode 10: Raid

10. Raid

7.5

Dangerous forces converge on Marshall's camp.

Cast

Photo of Dave King

Dave King

Marshall Cuso (voice)

Photo of Emily Pendergast

Emily Pendergast

Frances Applewhite (voice)

Photo of Mike Judge

Mike Judge

Rick Kruger (voice)

Photo of Martha Kelly

Martha Kelly

Agent Harrington (voice)

Photo of Joseph Lee Anderson

Joseph Lee Anderson

Agent Copano (voice)

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