Rya Kihlstedt

as Darlene Campbell

as Eleanor Miller

as Lyn Rakish (Fourth Sister) (voice)

as Fourth Sister

as Lisa Broad

as Holly

as Ally Allston

as Ally Allston / Bizarro Ally Allston

as Donetta

as Sandy Walker

as Sarah

as Ruth 'Coach' Simmons

as Helen

as Esther Jarret

as Roxy

as Dr. Julia Wagner

as Julia Wagner

as Rebecca

as Sam the Vet

as Mom

as Dr. Anna Nelson

as Barbara 'Babs' Brady

as Caroline

as Maggie

as Erica Kravid

as Beth

as Catherine Cross

as Judith Winstead

as Rita

as Tatti Greathouse

as Basha

as Jeannie

as Dr. McClain

as Marilyn Rhodes

as Elena Douglas

as Cleo Fox

as Rita

as Dr. Michelle Ross

as Claire

as Linda Idleton

as Mermaid

as Carolyn Logan

as Catherine

as Patricia 'Pat' Long

as Chloe

as Lenina Crowne

as Alice Ribbons

as Marcia Roberts Hobson

as Louisa

as Lizzy Elmsworth

as Jessie

as Anne Marie

as Willa